KMID : 1137020230340030031
|
|
Journal of Gynecologic Oncology 2023 Volume.34 No. 3 p.31 ~ p.31
|
|
The value of PET/CT for cytoreductive surgery selection in recurrent ovarian carcinoma
|
|
Rafael Leite Nunes
Flavio Rodrigues Teixeira Thiago Pereira Diniz Carlos Chaves Faloppa Henrique Mantoan Alexandre Andre Balieiro Anastacio da Costa Glauco Baiocchi
|
|
Abstract
|
|
|
Objective: To evaluate the value of positron emission tomography/computed tomography (PET/CT) in predicting no residual disease (NRD) after secondary cytoreductive surgery (SCS) compared with MSK criteria, the iMODEL, and the AGO score.
Methods: We analyzed 112 patients with platinum-sensitive ovarian carcinoma who underwent SCS. We excluded patients for whom PET/CT was not performed, those without sufficient data, and who received chemotherapy before SCS. Ultimately, 69 patients were included.
Results: Variables that correlated with NRD were peritoneal carcinomatosis index (odds ratio [OR]=0.91; 95% confidence interval [CI]=0.83?0.99; p=0.044), European Cooperative Oncology Group Performance Status (ECOG) 0 (OR=8.0; 95% CI=1.34?47.5; p=0.022), and ¡Â2 lesions by PET/CT (OR=4.36; 95% CI=1.07?17.7; p=0.039). Of the patients with ¡Â2 lesions by PET/CT, 48 (92.3%) underwent complete SCS. The sensitivity, positive predictive value, negative predictive value, and accuracy of PET/CT for NRD were 85.7%, 92.3%, 33.3%, and 81.2%, respectively. NRD was achieved after fulfilling the MSK criteria, iMODEL and AGO Score in 89.1%, 88.1% and 85.9%, respectively. The accuracy of the MSK criteria, iMODEL, and AGO score in predicting NRD was 87%, 83.3%, and 77.3%, respectively. The PET/CT findings agreed well with the AGO score and iMODEL. The addition of PET/CT to these models increased the NRD rates (92.2%, 91.8%, and 89.4% for MSK+PET/CT, iMODEL+PET/CT, and AGO+PET/CT, respectively), but lowered their accuracy.
Conclusion: We observed NRD in 92.3% of patients with ¡Â2 lesions by PET/CT, with an accuracy of 81.2%. PET/CT did not increase the accuracy of the MSK criteria, iMODEL, or AGO score models.
|
|
KEYWORD
|
|
Ovarian Cancer, Recurrence, Cytoreductive Surgery, Clinical Decision Rules, PET-CT
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|